Pseudogout in ochronosis

Alkaptonuric Ochronosis.

Alkaptonuria is an autosomal recessive metabolic disorder characterized by joints and spine involvement, ochronosis and presence of homogentisic acid in urine and its deposition in cartilage, intervertebral disc and other connective tissues, leading to disabling arthritis in elderly individual.

Cutaneous Markers in Ochronosis

Sir, A 40-year-old woman presented with low backache of five-year duration with pain in the knee, shoulder and ankle joints on both sides. On examination she was found to have thickened ear lobule with restricted mobility of pinna [Figure 1]. There was black pigmentation in the palmar aspect of the right index finger [Figure 2]. She also had hyperpigmented plaques with adherent scales in the le...

Monoarticular Hip Involvement in Pseudogout

Pseudogout is the acutest form of arthritis in the elderly. Although clinical manifestations vary widely, polyarticular involvement is typical mimicking osteoarthritis or rheumatoid arthritis. Monoarticular involvement is relatively rare and is generally provoked by another medical condition. There are reported cases of hip involvement by pseudogout in monoarticular form. However, all of the ca...

Achilles tendon enthesopathy in ochronosis.

Total knee arthroplasty in ochronosis

Alkaptonuria is disorder of tyrosine metabolism due to deficiency of homogentisic oxidase characterized by excretion of homogentisic acid in urine, deposition of oxidized homogensitate pigments in connective tissues and articular cartilages (ochronosis). The result is dark pigmentation and weakening of the tissues resulting in chronic inflammation and osteoarthritis. Management of alkaptonuric ...